Rutin is a flavonoid present in numerous fruits and vegetables and therefore widely
consumed by humans. It is also a popular dietary supplement of 250–500 mg/day. There is …

Introduction Suicidal behavior is relatively frequent in patients with bipolar disorder (BD) and
constitutes their most frequent cause of death. Suicide rates remain high in patients with BD …

Suicide is a global public health concern. There is evidence of an association between
suicidal behavior and depressive disorders (DDs). An increasing number of studies have …

Meloxicam has shown significant neuroprotection in experimental models of stroke,
Alzheimer's disease, and Parkinson's disease. However, the potential of meloxicam to treat …

The activation of microglia and the production of cytokines are key factors contributing to
progressive neurodegeneration. Despite the well-recognized neuronal programmed cell …

Depression is linked with oxidative stress and inflammation, where key players include nitric
oxide (NO), nuclear factor erythroid 2-related factor 2 (Nrf2), Brain-Derived Neurotrophic …

Abstract α-Pyrrolidinononanophenone (α-PNP) derivatives are known to be one of the
hazardous new psychoactive substances due to the most extended hydrocarbon chains of …

Growing evidence suggests that activators of nuclear factor erythroid-derived 2-like 2 (Nrf2),
such as sulforaphane, may represent promising novel pharmacological targets for …

Abstract Objectives Curcumae Rhizoma (CR) is a traditional Chinese medicine used
frequently in clinics, which contains volatile components that exhibit various active effects …

Depression is a global psychiatric disorder that imposes a substantial economic burden.
Trimetazidine (TMZ); a well-known anti-ischemic drug, could exert neuroprotection in …