Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

Abstract As of 15 August 2020, Coronavirus disease 2019 (COVID-19) has been reported
in> 21 million people world-wide and is responsible for more than 750,000 deaths. The …

Acute kidney injury (AKI) is a life-threatening condition that is one of most common side
effects of cisplatin therapy. Fatty acid oxidation (FAO) is the main source of energy …

The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte
and acid-base homeostasis and reabsorb nutrients. Energy depletion is a critical factor in …

Background Celastrol is an active ingredient of Chinese medicine Tripterygium wilfordii
which is clinically used to treat the immune diseases. Currently, celastrol is documented as a …

Acute kidney injury (AKI) causes considerable morbidity and mortality, particularly in the
case of post-cardiac infarction or kidney transplantation; however, the site-specific …

Ferroptosis, a form of regulated cell death, plays an important role in acute kidney injury
(AKI). Previous studies have shown that prolyl hydroxylase domain protein (PHD) inhibitors …

Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently
reported serious side-effect. However, there are no approved biomarkers that can properly …

Cisplatin is extensively used to treat malignancies. However, its clinical use is always limited
due to the serious side effects, especially the nephrotoxicity. Matrine (MAT), a tetracyclic …

Podocytes constitute the outer layer of the renal glomerular filtration barrier. Their energy
requirements strongly depend on efficient oxidative respiration, which is tightly connected …