Chemotherapy-induced myopathy: the dark side of the cachexia sphere

DG Campelj, CA Goodman, E Rybalka - Cancers, 2021 - mdpi.com
Simple Summary In addition to cancer-related factors, anti-cancer chemotherapy treatment
can drive life-threatening body wasting in a syndrome known as cachexia. Emerging …

Role of nutrition in patients with coexisting chronic obstructive pulmonary disease and sarcopenia

Y Nan, Y Zhou, Z Dai, T Yan, P Zhong, F Zhang… - Frontiers in …, 2023 - frontiersin.org
Chronic obstructive pulmonary disease (COPD) is one of the most common chronic
diseases in the elderly population and is characterized by persistent respiratory symptoms …

Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis

L Wang, XF Jiao, C Wu, XQ Li, HX Sun, XY Shen… - Cell death …, 2021 - nature.com
Skeletal muscle atrophy is one of the major side effects of high dose or sustained usage of
glucocorticoids. Pyroptosis is a novel form of pro-inflammatory programmed cell death that …

Daidzein alleviates cisplatin‐induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway

H Zhang, M Chi, L Chen, X Sun, L Wan… - Phytotherapy …, 2021 - Wiley Online Library
Cisplatin (DDP) is widely used in cancer treatment, but DDP can cause skeletal muscle
atrophy and cachexia. This study explored the effect and mechanism of daidzein (DAI) in …

Necroptosis mediates muscle protein degradation in a cachexia model of weanling pig with lipopolysaccharide challenge

J Guo, X Qin, Y Wang, X Li, X Wang, H Zhu… - International Journal of …, 2023 - mdpi.com
Necroptosis, an actively researched form of programmed cell death closely related to the
inflammatory response, is important in a variety of disorders and diseases. However, the …

The combination of quercetin and leucine synergistically improves grip strength by attenuating muscle atrophy by multiple mechanisms in mice exposed to cisplatin

TH Hsu, TJ Wu, YA Tai, CS Huang, JW Liao, SL Yeh - Plos one, 2023 - journals.plos.org
Both quercetin and leucine have been shown to exert moderately beneficial effects in
preventing muscle atrophy induced by cancers or chemotherapy. However, the combined …

Proteomic analysis reveals that Polygonatum cyrtonema Hua polysaccharide ameliorates mice muscle atrophy in chemotherapy-induced cachexia

X Tang, J Xie, Y Qin, H Liu, F Cheng, H Zhang… - … of Pharmaceutical and …, 2023 - Elsevier
Polygonatum cyrtonema Hua polysaccharide (PCP) is the main bioactive compound derived
from the herb Polygonati Rhizoma, known for its anti-fatigue, antioxidant …

Role of mitochondrial dysfunction in the pathogenesis of cisplatin-induced myotube atrophy

C Matsumoto, H Sekine, M Nahata… - Biological and …, 2022 - jstage.jst.go.jp
Muscle atrophy is commonly observed during cisplatin chemotherapy, leading to a reduced
QOL in cancer patients. Reduced skeletal muscle mass caused by cisplatin treatment results …

Photobiomodulation therapy moderates cancer cachexia-associated muscle wasting through activating PI3K/AKT/FoxO3a pathway

Y Li, Y Chen, Y Liao, T Huang, Q Tang, C He, L Xu… - Apoptosis, 2024 - Springer
Cancer cachexia-associated muscle wasting as a multifactorial wasting syndrome, is an
important factor affecting the long-term survival rate of tumor patients. Photobiomodulation …

Kaempferol‐Enhanced Migration and Differentiation of C2C12 Myoblasts via ITG1B/FAK/Paxillin and IGF1R/AKT/mTOR Signaling Pathways

TC Hour, NT Lan Nhi, IJ Lai, CP Chuu… - Molecular Nutrition & …, 2024 - Wiley Online Library
Scope Kaempferol (KMP), a bioactive flavonoid compound found in fruits and vegetables,
contributes to human health in many ways but little is known about its relationship with …