Fat is a vital macronutrient, and its intake is closely monitored by an array of molecular
sensors distributed throughout the alimentary canal. In the mouth, dietary fat constituents …

Obesity is damaging the lives of more than 300 million people worldwide and maintaining a
healthy weight using popular weight loss tactics remains a very difficult undertaking …

Chronic pain is associated with anhedonia and decreased motivation. These behavioral
alterations have been linked to alterations in the limbic brain and could explain the …

Chronic low back pain (CLBP) and obesity are interrelated, but the physiological
mechanisms linking the 2 conditions remain to be determined. Functional brain imaging …

Background The reward deficiency syndrome hypothesis posits that genes are responsible
for reward dependence and related behaviors. There is evidence that both bulimia and …

OBJECTIVE: One developing strategy for obesity treatment has been to use combinations of
differently acting pharmacotherapies to improve weight loss with fewer adverse effects. The …

Background: Preference for fatty foods is a risk factor for obesity. It is a complex behaviour
that involves the brain reward system and is regulated by genetic and environmental factors …

Blockade of opioidergic neurotransmission contributes to reduction in body weight.
However, how such blockade affects body weight gain (BWG) attributed to second …

A high-fat diet (HFD) and loss of endogenous estrogens increases the risk for type 2
diabetes (T2D) and insulin resistance. Although exercise is known to prevent and manage …

Rationale Intra-striatal infusions of the muscarinic antagonist, scopolamine, markedly
suppress feeding; however, the underlying mechanisms are unclear. Recent findings …