Due to their topology tail-anchored (TA) proteins must target to the membrane independently
of the co-translational route defined by the signal sequence recognition particle (SRP), its …

The type-2 peroxisomal targeting signal (PTS2) is one of two peptide motifs destining
soluble proteins for peroxisomes. This signal acts as amphiphilic α-helix exposing the side …

Peroxisomes are ubiquitous, oxidative subcellular organelles with important functions in
cellular lipid metabolism and redox homeostasis. Loss of peroxisomal functions causes …

Although autophagy regulates the quality and quantity of cellular compartments, the
regulatory mechanisms underlying peroxisomal autophagy (pexophagy) remain largely …

The involvement of peroxisomes in cellular hydrogen peroxide (H2O2) metabolism has
been a central theme since their first biochemical characterization by Christian de Duve in …

Peroxisomes are small, single-membrane specialized organelles present in all eukaryotic
organisms. The peroxisome is one of the nodal centers of reactive oxygen species …

Single nucleotide variants (SNVs) resulting in amino acid substitutions (ie, missense
variants) can affect protein localization by changing or creating new targeting signals. Here …

The toxin hemolysin A was first identified in uropathogenic E. coli strains and shown to be
secreted in a one-step mechanism by a dedicated secretion machinery. This machinery …

Most soluble proteins enclosed in peroxisomes encode either type-1 or type-2 peroxisomal
targeting signals (PTS1 or PTS2), which act as postal codes and define the proteins' …

The import of many peroxisomal matrix proteins is initiated by the interaction of type-1
peroxisomal targeting signals (PTS1) residing at the extreme C-terminus of cargo proteins …