Self-emulsifying oral lipid drug delivery systems: advances and challenges
The attempts to oral delivery of lipids can be challenging. Self-emulsifying drug delivery
system (SEDDS) plays a vital role to tackle this problem. SEDDS is composed of an oil …
system (SEDDS) plays a vital role to tackle this problem. SEDDS is composed of an oil …
Fast-fed variability: insights into drug delivery, molecular manifestations, and regulatory aspects
N Rangaraj, S Sampathi, V Junnuthula, P Kolimi… - Pharmaceutics, 2022 - mdpi.com
Among various drug administration routes, oral drug delivery is preferred and is considered
patient-friendly; hence, most of the marketed drugs are available as conventional tablets or …
patient-friendly; hence, most of the marketed drugs are available as conventional tablets or …
Enhanced oral bioavailability of Rivaroxaban-Loaded microspheres by optimizing the polymer and surfactant based on molecular interaction mechanisms
This study aimed to develop microspheres using water-soluble carriers and surfactants to
improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded …
improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded …
Design and development of permeation enhancer containing self-nanoemulsifying drug delivery system (SNEDDS) for ceftriaxone sodium improved oral …
T Kanwal, M Kawish, R Maharjan, I Ghaffar… - Journal of Molecular …, 2019 - Elsevier
Ceftriaxone sodium cannot be delivered orally due to its lower permeability and gastric
instability. Self-nanoemulsifying drug delivery systems (SNEDDS) spontaneously form oil-in …
instability. Self-nanoemulsifying drug delivery systems (SNEDDS) spontaneously form oil-in …
Self-nanoemulsifying drug delivery system of fisetin: Formulation, optimization, characterization and cytotoxicity assessment
Fisetin is a plant derived flavonoid that possesses anti-cancer, anti-oxidant and anti-
Parkinson's activities. However, due to its lipophilicity it suffers from dissolution rate limited …
Parkinson's activities. However, due to its lipophilicity it suffers from dissolution rate limited …
Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDSs) for senicapoc
Senicapoc (SEN), a potent antisickling agent, shows poor water solubility and poor oral
bioavailability. To improve the solubility and cell permeation of SEN, self-nanoemulsifying …
bioavailability. To improve the solubility and cell permeation of SEN, self-nanoemulsifying …
Coconut oil based self-nano emulsifying delivery systems mitigate ulcerogenic NSAIDs side effect and enhance drug dissolution: Formula optimization, in-vitro, and in …
Gastric ulcer is a common gastrointestinal ailment that affects many people worldwide.
NSAIDs induced ulcers are the second most common etiology of gastric ulcers. Coconut oil …
NSAIDs induced ulcers are the second most common etiology of gastric ulcers. Coconut oil …
[HTML][HTML] Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs
Y Meng, F Tan, J Yao, Y Cui, Y Feng, Z Li… - International Journal of …, 2022 - Elsevier
Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of
RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to …
RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to …
Comparison of the physicochemical properties, aqueous solubility, and oral bioavailability of rivaroxaban-loaded high-pressure homogenised and Shirasu porous …
MJ Choi, JS Kim, H Yu, MR Woo, JE Choi… - Journal of Molecular …, 2022 - Elsevier
This study aimed to compare high-pressure homogenization (HPH) and Shirasu porous
glass (SPG) membrane emulsification for enhancing the oral bioavailability of rivaroxaban …
glass (SPG) membrane emulsification for enhancing the oral bioavailability of rivaroxaban …
In vivo evaluation of time-dependent antithrombotic effect of rivaroxaban-loaded poly (lactic-co-glycolic acid)/sodium lauryl sulfate or didodecyl dimethylammonium …
P de Souza Furtado, AASC de Oliveira… - European Journal of …, 2023 - Elsevier
Rivaroxaban (RVX), an oral direct factor Xa inhibitor, is being explored as an alternative to
traditional anticoagulans. However, RVX still faces pharmacokinetic limitations and adverse …
traditional anticoagulans. However, RVX still faces pharmacokinetic limitations and adverse …