Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …

Background Enhanced angiogenesis can promote diabetic wound healing. Mesenchymal
stem cells (MSCs)-derived exosomes, which are cell-free therapeutics, are promising …

Osteoarthritis (OA) is the most common disabling joint disease throughout the world and its
therapeutic effect is still not satisfactory in clinic nowadays. Recent studies showed that the …

Mesenchymal stem cell (MSC) exosome was previously shown to be effective in repairing
critical size osteochondral defects in an immunocompetent rat model. Here we investigate …

Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects
in articular cartilage can induce debilitating degenerative joint diseases such as …

Objectives: Intervertebral disc degeneration (IDD) is widely accepted as a cause of low back
pain and related degenerative musculoskeletal disorders. Nucleus pulposus (NP) cell …

Background WNT5A is known to be involved in the pathogenesis of osteoarthritis. This study
investigated the molecular mechanism of exosomal miR-92a-3p and WNT5A in …

Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …

Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and
disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not …