Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis

U Kariholu, P Montaldo, T Markati, PJ Lally… - Archives of Disease in …, 2020 - fn.bmj.com
Objectives To examine if therapeutic hypothermia reduces the composite outcome of death,
moderate or severe disability at 18 months or more after mild neonatal encephalopathy …

Unanswered questions regarding therapeutic hypothermia for neonates with neonatal encephalopathy

H Sabir, SL Bonifacio, AJ Gunn, M Thoresen… - Seminars in Fetal and …, 2021 - Elsevier
Therapeutic hypothermia (TH) is now well established to improve intact survival after
neonatal encephalopathy (NE). However, many questions could not be addressed by the …

Networks of cortical activity show graded responses to perinatal asphyxia

T Syvälahti, A Tuiskula, P Nevalainen… - Pediatric …, 2024 - nature.com
Background Perinatal asphyxia often leads to hypoxic-ischemic encephalopathy (HIE) with a
high risk of neurodevelopmental consequences. While moderate and severe HIE link to high …

Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study

L Shipley, C Gale, D Sharkey - Archives of Disease in Childhood-Fetal …, 2021 - fn.bmj.com
Objective Hypoxic-ischaemic encephalopathy (HIE) remains a leading cause of neonatal
mortality and neurodisability. We aimed to determine the incidence of HIE and management …

Impact of hypoxia-ischemia on neurogenesis and structural and functional outcomes in a mild–moderate neonatal hypoxia-ischemia brain injury model

A Ehlting, M Zweyer, E Maes, Y Schleehuber, H Doshi… - Life, 2022 - mdpi.com
Hypoxic-ischemic encephalopathy (HIE) is a common type of brain injury caused by a lack of
oxygen and blood flow to the brain during the perinatal period. The incidence of HIE is …

The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status

JS Dumbuya, L Chen, JY Wu, B Wang - Journal of Neuroinflammation, 2021 - Springer
Hypoxic-ischemic encephalopathy (HIE) is an important cause of permanent damage to
central nervous system (CNS) that may result in neonatal death or manifest later as mental …

The physiological effects of creatine supplementation in fetal sheep before, during, and after umbilical cord occlusion and global hypoxia

NT Tran, AM Muccini, RJ Snow… - Journal of Applied …, 2021 - journals.physiology.org
The aim of this study was to investigate the effects of direct creatine infusion on fetal
systemic metabolic and cardiovascular responses to mild acute in utero hypoxia. Pregnant …

Brain injury following mild hypoxic-ischemic encephalopathy in neonates–ten-year experience in a tertiary perinatal center

T Imanishi, M Shimizu, W Sumiya, C Kanno… - Journal of …, 2022 - nature.com
Objective We aimed to evaluate abnormal magnetic resonance imaging (MRI) findings in
neonates with mild hypoxic-ischemic encephalopathy (HIE). Study design This was a single …

Environmental Enrichment Enhances Cav 2.1 Channel-Mediated Presynaptic Plasticity in Hypoxic–Ischemic Encephalopathy

SY Song, S Pyo, S Choi, HS Oh, JH Seo, JH Yu… - International journal of …, 2021 - mdpi.com
Hypoxic–ischemic encephalopathy (HIE) is a devastating neonatal brain condition caused
by lack of oxygen and limited blood flow. Environmental enrichment (EE) is a classic …

Hypothermia after perinatal asphyxia does not affect genes responsible for amyloid production in neonatal peripheral lymphocytes

A Tarkowska, W Furmaga-Jabłońska, J Bogucki… - Journal of Clinical …, 2022 - mdpi.com
In this study, the expression of the genes of the amyloid protein precursor, β-secretase,
presenilin 1 and 2 by RT-PCR in the lymphocytes of newborns after perinatal asphyxia and …