Advances of droplet-based microfluidics in drug discovery

Y Wang, Z Chen, F Bian, L Shang, K Zhu… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction Drug discovery through a large number of candidates with nearly unlimited
possibilities is laborious, time-consuming, and incurs massive costs. It thus calls for fast and …

Microfluidic-Assisted Caenorhabditis elegans Sorting: Current Status and Future Prospects

H Yuan, W Yuan, S Duan, K Jiao, Q Zhang… - Cyborg and Bionic …, 2023 - spj.science.org
Caenorhabditis elegans (C. elegans) has been a popular model organism for several
decades since its first discovery of the huge research potential for modeling human diseases …

[HTML][HTML] Deep Learning for Microfluidic-Assisted Caenorhabditis elegans Multi-Parameter Identification Using YOLOv7

J Zhang, S Liu, H Yuan, R Yong, S Duan, Y Li… - Micromachines, 2023 - mdpi.com
The Caenorhabditis elegans (C. elegans) is an ideal model organism for studying human
diseases and genetics due to its transparency and suitability for optical imaging. However …

Ce Lab, a microfluidic platform for the study of life history traits, reveals metformin and SGK-1 regulation of longevity and reproductive span

S Sohrabi, V Cota, CT Murphy - Lab on a Chip, 2023 - pubs.rsc.org
The potential to carry out high-throughput assays in a whole organism in a small space is
one of the benefits of C. elegans, but worm assays often require a large sample size with …

[HTML][HTML] Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective Drugs

S Bulterijs, BP Braeckman - Pharmaceuticals, 2020 - mdpi.com
Population aging is one of the largest challenges of the 21st century. As more people live to
advanced ages, the prevalence of age-related diseases and disabilities will increase …

Microfluidic approaches for Caenorhabditis elegans research

E Levine, KS Lee - Animal cells and systems, 2020 - Taylor & Francis
In the last decade, microfluidic methods have proven to be powerful tools for Caenorhabditis
elegans research, offering advanced manipulation of worms and precise control of …

Green microfluidics in microchemical engineering for carbon neutrality

Q Ma, J Xu - Chinese Journal of Chemical Engineering, 2023 - Elsevier
The concept of “carbon neutrality” poses a huge challenge for chemical engineering and
brings great opportunities for boosting the development of novel technologies to realize …

The triggering pathway, the metabolic amplifying pathway, and cellular transduction in regulation of glucose-dependent biphasic insulin secretion

S Bisht, MF Singh - Archives of Physiology and Biochemistry, 2024 - Taylor & Francis
Introduction: Insulin secretion is a highly regulated process critical for maintaining glucose
homeostasis. This abstract explores the intricate interplay between three essential …

[HTML][HTML] Combating parasitic nematode infections, newly discovered antinematode compounds from marine epiphytic bacteria

NH Salikin, J Nappi, ME Majzoub, S Egan - Microorganisms, 2020 - mdpi.com
Parasitic nematode infections cause debilitating diseases and impede economic
productivity. Antinematode chemotherapies are fundamental to modern medicine and are …

Advances in C. áelegans behavior research with microfluidic devices and its future prospects in the evaluation of exogenous pollutants

X Zhang, J Sun, X Yuan, X Lu, X Sun - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
The nematode Caenorhabditis elegans (C. áelegans) is characterized by small size, a
transparent body, and a simple structure. However, traditional techniques (eg, sorting and …