Dabigatran in the treatment and secondary prophylaxis of venous thromboembolism in children with thrombophilia

LR Brandão, I Tartakovsky, M Albisetti, J Halton… - Blood …, 2022 - ashpublications.org
In the phase 2b/3 DIVERSITY trial, 3 months treatment with dabigatran was noninferior to
standard of care (SOC) for acute venous thromboembolism (VTE) in children. In a single …

Unraveling the pathophysiology of lower-limb postthrombotic syndrome in adolescents: a proof-of-concept study

ML Avila, RF Bentley, D Bastas, LR Brandão… - Blood …, 2023 - ashpublications.org
A better understanding of the pathophysiology of pediatric postthrombotic syndrome (PTS) is
needed to develop strategies to treat this condition. We investigated calf pump function …

Dabigatran for Treatment and Secondary Prevention of Venous Thromboembolism in Pediatric Congenital Heart Disease

M Albisetti, I Tartakovsky, J Halton… - Journal of the …, 2024 - Am Heart Assoc
Background Congenital heart disease (CHD) is common in children and associated with
greater risk of thrombotic complications. Management of these complications with standard …

[HTML][HTML] The role of coagulation factors VIII, IX and XI in the prediction and mediation of recurrent thrombotic events in children with non-central venous catheter deep …

A Bosch, KB Jarvis, LR Brandão, Y Zou, J Vincelli… - Thrombosis …, 2024 - Elsevier
Background The role of elevated coagulation factors VIII (FVIII), FIX, FXI for the prediction of
recurrent thrombotic events in children after an index non-central venous catheter (non …

[HTML][HTML] Functional impact of pediatric postthrombotic syndrome

D Bastas, LR Brandão, DD Allen, J Vincelli… - Journal of Thrombosis …, 2023 - Elsevier
Background Postthrombotic syndrome (PTS) is the most common complication of deep vein
thrombosis (DVT) in children. Objectives We aimed to assess the impact of pediatric PTS on …

Anticoagulant Therapy for 6 Weeks vs 3 Months and Recurrence and Bleeding in Patients Younger Than 21 Years With Provoked Venous Thromboembolism—Reply

NA Goldenberg, LR Brandão, C Male… - JAMA, 2022 - jamanetwork.com
To the EditorWe have several comments about the recent study1 investigating the effect of
anticoagulant therapy for 6 weeks vs 3 months on recurrence and bleeding in patients …

Clinical care of pediatric patients with or at risk of postthrombotic syndrome: guidance from the ISTH SSC Subcommittee on pediatric and neonatal thrombosis and …

L Avila, M Betensky, C Cohen, S Ahuja… - Journal of Thrombosis …, 2024 - Elsevier
2. Methods The WG developed the document, anchored on an updated systematic review of
pediatric PTS [12]. To guide the systematic review, the WG prioritized 10 relevant …

[HTML][HTML] Impact of deep vein thrombosis on adolescent athletes: navigating an invisible disability

D Bastas, J Vincelli, R De, E Benia, S Gairdner… - Research and Practice …, 2022 - Elsevier
Background Injury in adolescent athletes that threatens their sport participation can result in
a sense of identity loss during critical years for identity development, creating the potential …

[HTML][HTML] Compression garments for the management of pediatric post‐thrombotic syndrome: A prospective longitudinal study

L Avila, N Amiri, R De, J Vincelli… - Journal of Thrombosis …, 2021 - Elsevier
Background Graduated compression garments (CG) are a standard form of management of
post‐thrombotic syndrome (PTS) in adults, but data in children are lacking. Objectives We …

Study on the effect and mechanism of miR-185 on lower extremity deep venous thrombosis

R Lu, W Zhu, H Sun, L Zhang, Z Yu, Z Nie… - Molecular Biotechnology, 2022 - Springer
Lower extremity deep venous thrombosis (LEDVT) is a venous reflux disorder caused by
abnormal coagulation of blood. LEDVT can obstruct the lumen and LEDVT is the third …