Contralateral breast cancer risk among carriers of germline pathogenic variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2
PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with
germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 …
germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 …
[HTML][HTML] Biological Basis of Breast Cancer-Related Disparities in Precision Oncology Era
AN Neagu, P Bruno, KR Johnson, G Ballestas… - International Journal of …, 2024 - mdpi.com
Precision oncology is based on deep knowledge of the molecular profile of tumors, allowing
for more accurate and personalized therapy for specific groups of patients who are different …
for more accurate and personalized therapy for specific groups of patients who are different …
Disparities in genetic testing for heritable solid-tumor malignancies
J Dillon, FO Ademuyiwa, M Barrett… - Surgical Oncology …, 2022 - surgonc.theclinics.com
Advances in cancer genetics, targeted therapies, and risk reduction strategies have greatly
transformed the field of oncology. Genetic testing is now an essential tool in the identification …
transformed the field of oncology. Genetic testing is now an essential tool in the identification …
Diagnostic outcomes of concurrent DNA and RNA sequencing in individuals undergoing hereditary cancer testing
C Horton, L Hoang, H Zimmermann, C Young… - JAMA …, 2024 - jamanetwork.com
Importance Personalized surveillance, prophylaxis, and cancer treatment options for
individuals with hereditary cancer predisposition are informed by results of germline genetic …
individuals with hereditary cancer predisposition are informed by results of germline genetic …
[HTML][HTML] Germline pathogenic variants in cancer predisposition genes among women with invasive lobular carcinoma of the breast
PURPOSE To determine the contribution of germline pathogenic variants (PVs) in hereditary
cancer testing panel genes to invasive lobular carcinoma (ILC) of the breast. MATERIALS …
cancer testing panel genes to invasive lobular carcinoma (ILC) of the breast. MATERIALS …
Comparison of the prevalence of pathogenic variants in cancer susceptibility genes in black women and non-hispanic white women with breast cancer in the United …
Importance The prevalence of germline pathogenic variants (PVs) in cancer susceptibility
genes in US Black women compared with non-Hispanic White women with breast cancer is …
genes in US Black women compared with non-Hispanic White women with breast cancer is …
[HTML][HTML] Relationship between Telomere Length, TERT Genetic Variability and TERT, TP53, SP1, MYC Gene Co-Expression in the Clinicopathological Profile of …
M Dratwa, B Wysoczanska, W Brankiewicz… - International journal of …, 2022 - mdpi.com
The molecular mechanisms of telomerase reverse transcriptase (TERT) upregulation in
breast cancer (BC) are complex. We compared genetic variability within TERT and telomere …
breast cancer (BC) are complex. We compared genetic variability within TERT and telomere …
[HTML][HTML] Functional and clinical characterization of variants of uncertain significance identifies a hotspot for inactivating missense variants in RAD51C
C Hu, AB Nagaraj, H Shimelis, G Montalban, KY Lee… - Cancer research, 2023 - AACR
Pathogenic protein-truncating variants of RAD51C, which plays an integral role in promoting
DNA damage repair, increase the risk of breast and ovarian cancer. A large number of …
DNA damage repair, increase the risk of breast and ovarian cancer. A large number of …
[HTML][HTML] Prevalence of BRCA1 and BRCA2 pathogenic variants in 8627 unselected patients with breast cancer: stratification of age at diagnosis, family history and …
F Zang, X Ding, J Chen, L Hu, J Sun, J Zhang… - Breast Cancer Research …, 2022 - Springer
Purpose Comprehensively analyzing the prevalence of BRCA1/2 germline pathogenic
variants (PVs) in a large cohort of unselected Chinese patients with breast cancer has great …
variants (PVs) in a large cohort of unselected Chinese patients with breast cancer has great …
[HTML][HTML] Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities
C Chen, CJ Lin, YC Pei, D Ma, L Liao, SY Li, L Fan… - Cell Discovery, 2023 - nature.com
Germline-somatic mutation interactions are universal and associated with tumorigenesis, but
their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We …
their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We …