Maternally expressed gene 3 (MEG3) is a noncoding RNA highly expressed in the normal
human brain and pituitary. Expression of MEG3 is lost in gonadotroph-derived clinically …

Vascular endothelial growth factor (VEGF) signal transduction through receptor tyrosine
kinases VEGF receptor-1,-2 and-3 is of crucial importance for monocytes/macrophages …

Reactive oxygen species (ROS), in particular, H2O2, is essential for full activation of VEGF
receptor2 (VEGFR2) signaling involved in endothelial cell (EC) proliferation and migration …

Abstract Objective: Cyclooxygenase-2 (COX-2) is induced by hypoxic stimuli and is also
involved in the process of angiogenesis. We previously demonstrated that vascular …

Vascular endothelial growth factor‐A (VEGF‐A) induces actin reorganization and migration
of endothelial cells through a p38 mitogen‐activated protein kinase (MAPK) pathway. LIM …

Vascular endothelial growth factor (VEGF)–A regulates vascular development and
angiogenesis. VEGF isoforms differ in ability to bind coreceptors heparan sulfate (HS) and …

Rationale: Pulmonary arterial hypertension (PAH) is characterized by significant exercise
intolerance, which is multifactorial and involves skeletal muscle alterations. There is growing …

VEGFR-2 is the major receptor that regulates the different functions of VEGF in adults. We
have previously reported that following VEGF treatment of endothelial cells, VEGFR-2 is …

Sprouting blood vessels are led by filopodia-studded endothelial tip cells that respond to
angiogenic signals. Mosaic lineage tracing previously revealed that NRP1 is essential for tip …

Vascular endothelial growth factor (VEGF) binding induces phosphorylation of VEGF
receptor (VEGFR) 2 in tyrosine, which is followed by disruption of VE-cadherin–mediated …