Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …

Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of
membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from …

How amphipathic phospholipids are shuttled between the membrane bilayer remains an
essential but elusive process, particularly at the endoplasmic reticulum (ER). One prominent …

Efficient delivery of specific cargos in vivo poses a major challenge to the secretory pathway,
which shuttles products encoded by∼ 30% of the genome. Newly synthesized protein and …

Digested dietary fats are taken up by enterocytes where they are assembled into pre-
chylomicrons in the endoplasmic reticulum followed by transport to the Golgi for maturation …

Precise control of circulating lipids is instrumental in health and disease. Bulk lipids, carried
by specialized lipoproteins, are secreted into the circulation, initially via the coat protein …

Cholesterol transport between intracellular compartments proceeds by both energy-and non-
energy-dependent processes. Energy-dependent vesicular traffic partly contributes to …

Understanding organelle biogenesis is a central focus of cell biology. Whereas some are
generated from existing organelles, others can be generated de novo. Most de novo …

G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma
membrane seven times (hence, are also called 7TM receptors). The polytopic structure of …

Highlights•The plant vacuole is the major site for sugar storage.•The activities of vacuolar
sugar porters determine plant yield and stress tolerance.•The vacuole is energized by two …