The liver, the largest solid visceral organ of the body, has numerous endocrine functions,
such as direct hormone and hepatokine production, hormone metabolism, synthesis of …

Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur
exclusively via the replication of existing beta cells, but clinically meaningful restoration of …

Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent chronic metabolic disorders,
and insulin has been placed at the epicentre of its pathophysiological basis. However, the …

Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …

The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue
regeneration and an appealing therapeutic target. However, its clinical exploitation is …

Novel strategies are being developed to generate stem-cell-derived insulin-producing cells
(IPCs), which could reverse the growing incidence of diabetes worldwide. We reviewed …

The alpha cells that coinhabit the islets with the insulin-producing beta cells have recently
captured the attention of diabetes researchers because of new breakthrough findings …

The existence of interindividual variations in G protein-coupled receptor sequences has
been recognized early on. Recent advances in large-scale exon sequencing techniques are …

Most studies in type 1 diabetes (T1D) have focused on the loss of the pancreatic beta-cell
population. However, despite the involvement of the alpha-cell in the aetiology and …