Recent advances in cryo-electron microscopy have marked only the beginning of the
potential of this technique. To bring structure into cell biology, the modality of cryo-electron …

To infect and cause disease, bacterial pathogens must localize to specific regions of the host
where they possess the metabolic and defensive acumen for survival. Motile flagellated …

We advance an account that grounds cognition, specifically decision-making, in an activity
all organisms as autonomous systems must perform to keep themselves viable—controlling …

Escherichia coli phage SU10 belongs to the genus Kuravirus from the class Caudoviricetes
of phages with short non-contractile tails. In contrast to other short-tailed phages, the tails of …

Cryo-electron tomography (cryo-ET) and subtomogram averaging (STA) are increasingly
used for macromolecular structure determination in situ. Here, we introduce a set of …

The abuse of antibiotics has led to the emergence of multidrug-resistant microbial
pathogens, presenting a pressing challenge in global healthcare. Membrane-disrupting …

Bacterial type IV secretion systems (T4SSs) are highly versatile macromolecular
translocators and offer great potential for deployment as delivery systems for therapeutic …

Visualizing macromolecules inside bacteria at a high spatial resolution has remained a
challenge owing to their small size and limited resolution of optical microscopy techniques …

Two-component systems (TCS) are widespread signaling systems present in all domains of
life. TCS typically consist of a signal receptor/transducer and a response regulator. The …

Chemotaxis signaling pathways enable bacteria to sense and respond to their chemical
environment and, in some species, are critical for lifestyle processes such as biofilm …