Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality that show
promise to open a target space not accessible to conventional small molecules via a …

The pursuit of single drugs targeting multiple targets has become a prominent trend in
modern cancer therapeutics. Natural products, known for their multi-targeting capabilities …

Abstract Hexokinase 2 (HK2) is the rate-limiting enzyme in the first step of glycolysis,
catalyzing glucose to glucose-6-phosphate, and overexpressed in most cancer cells. HK2 …

The epidermal growth factor receptor (EGFR) has been well validated as a therapeutic target
for anticancer drug discovery. Osimertinib has become the first globally accessible third …

Protein tyrosine phosphorylation is a post-translational modification that regulates protein
structure to modulate demic organisms' homeostasis and function. This physiological …

The development of various heterobifunctional constructs dubbed PRoteolysis-TArgeting
Chimeras (PROTACs) has gained a significant impetus in the last few years. A viable …

The global spread of severe acute respiratory syndrome corona virus-2 (SARS-CoV-2)
variants is alarming. In addition to vaccines, effective antiviral agents are urgently needed to …

There is great demand for the development of novel efficient therapeutic strategies or
preventative measures to alleviate the life-threatening complications of type 2 diabetes …

Gastric cancer remains the fourth most frequently diagnosed malignancy and the fifth
leading cause of cancer-related mortality worldwide owning to the lack of efficient drugs and …

Targeted protein degradation (TPD) is an emerging tool for degrading proteins of interest,
which affords an attractive modality for cancer therapy. However, the present TPD …