Zooming in and out of ferroptosis in human disease

X Wang, Y Zhou, J Min, F Wang - Frontiers of Medicine, 2023 - Springer
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid
peroxidation. In the past decade, it has been implicated in the pathogenesis of various …

Liraglutide attenuates hepatic iron levels and ferroptosis in db/db mice

JX Song, JR An, Q Chen, XY Yang, CL Jia, S Xu… - …, 2022 - Taylor & Francis
Liver pathological changes are as high as 21%-78% in diabetic patients, and treatment
options are lacking. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor that is widely …

Ferroptosis and metabolic syndrome and complications: association, mechanism, and translational applications

D Zhou, P Lu, X Mo, B Yang, T Chen, Y Yao… - Frontiers in …, 2024 - frontiersin.org
Metabolic syndrome is a medical condition characterized by several metabolic disorders in
the body. Long-term metabolic disorders raise the risk of cardiovascular disease (CVD) and …

[HTML][HTML] Mucin secretory action of capsaicin prevents high fat diet-induced gut barrier dysfunction in C57BL/6 mice colon

V Kumar, V Kumar, N Mahajan, J Kaur, K Devi… - Biomedicine & …, 2022 - Elsevier
The gut barrier–including tight junction proteins (TJPs) and mucus layers, is the first line of
defense against physical, chemical or pathogenic incursions. This barrier is compromised in …

Sesamol Mitigates Chronic Iron Overload‐Induced Cognitive Impairment and Systemic Inflammation via IL‐6 and DMT1 Regulation

Y Wang, Y Zhang, X Wang, Q Li, Y Zhao… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Excessive iron contributes to oxidative damage and cognitive decline in Alzheimer's
disease. Sesamol, a compound in sesame oil that exhibits both anti‐inflammatory and …

Regulation of a high-iron diet on lipid metabolism and gut microbiota in mice

Q Xiong, J Zhao, C Tian, W Ma, L Miao, L Liang… - Animals, 2022 - mdpi.com
Simple Summary Iron is an essential micronutrient involved in many important physiological
activities and plays a key role in growth and development of animals. However, exposure to …

[HTML][HTML] Iron homeostasis and energy metabolism in obesity

SL Kim, S Shin, SJ Yang - Clinical nutrition research, 2022 - ncbi.nlm.nih.gov
Iron plays a role in energy metabolism as a component of vital enzymes and electron
transport chains (ETCs) for adenosine triphosphate (ATP) synthesis. The tricarboxylic acid …

Targeting ferroptosis in cardio‐metabolic‐diseases: Mechanisms and therapeutic prospects

JB Zhang, J Tong, DY Sun, JT Fu… - Medicinal research …, 2023 - Wiley Online Library
Abstract Cardio‐metabolic‐diseases (cardio‐metabolic‐diseases) are leading causes of
death and disability worldwide and impose a tremendous burden on whole society as well …

Effects of high dietary iron on the lipid metabolism in the liver and adipose tissue of male broiler chickens

S Bai, W Luo, H Liu, K Zhang, J Wang, X Ding… - Animal Feed Science …, 2021 - Elsevier
Iron overload is associated with the obesity and type 2 diabetes in humans. To investigate its
effects on lipid metabolism in the liver and adipose tissue of broiler chickens, a total of 320 1 …

Secondary iron overload induces chronic pancreatitis and ferroptosis of acinar cells in mice

C Tian, J Zhao, Q Xiong, H Yu… - … Journal of Molecular …, 2022 - spandidos-publications.com
Disruption of iron homeostasis is associated with multiple diseases. It has been found that
patients with genetic iron overload develop massive iron deposition in the pancreas …