When Ig chains were first sequenced, segments within the constant regions of H and L
chains showed sequence similarities, and this led to the idea that the Ig chains had all …

Publisher Summary Because cytokine functions are complex and overlapping, the
development of precise, monospecific bioassays, and enzyme-linked immunosorbent …

Lymphokine synthesis patterns of a panel of 19 T cell clones have been evaluated, using
mRNA hybridization methods to examine 11 different mRNAs induced by Con A. The two …

Objective.—To test the hypothesis that peripheral blood mononuclear cells in women with
unexplained recurrent abortion (URA) produce T-helper 1 (TH 1)—type cytokines in …

Studies with perforin-deficient mice have demonstrated that two independent mechanisms
account for T cell–mediated cytotoxicity: A main pathway is mediated by the secretion of the …

Lymphocytes mediate many important functions of the immune system, such as antibody
production, cytotoxicity, and immediate and delayed type hypersensitivity (DTH). In 1968 …

CD4+ T cells, via the cytokines that they produce, play a pivotal role in the induction and
regulation of cell-mediated and humoral immunity. Recently it has become clear that the …

Antigen priming of naive CD4 T cells can generate effector CD4 T cells that produce
interleukin 4 (T helper [Th] 2-like) or interferon-gamma (Th1-like). Using a system in which …

T cells bearing CD4 recognize antigen in association with class II MHC molecules. Such
cells have a variety of different functions. In this review, Kim Bottomly summarizes recent …

The interaction between helper T cells and B cells, leading to the production of antibody to
thymus-dependent antigens, was the first cell interaction clearly defined in the immune …