Topoisomerases are ubiquitous enzymes that control DNA supercoiling and entanglements.
They are essential during transcription and replication, and topoisomerase inhibitors are …

Recent molecular studies have expanded the biological contexts in which topoisomerase II
(TOP2) has crucial functions, including DNA replication, transcription and chromosome …

The capacity of doxorubicin to inhibit topoisomerase II in the MCF-7 breast tumor cell line is
supported by the induction of protein-associated single-strand breaks in DNA, as well as by …

Topoisomerase II is an essential enzyme that is required for virtually every process that
requires movement of DNA within the nucleus or the opening of the double helix. This …

Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of
human cancers. It has been in clinical use for more than two decades and remains one of …

The Centers for Disease Control and the World Health Organization have issued a list of
priority pathogens for which there are dwindling therapeutic options, including antibiotic …

Type II topoisomerases are ubiquitous enzymes that play essential roles in a number of
fundamental DNA processes. They regulate DNA under-and overwinding, and resolve knots …

Topoisomerase II is a ubiquitous enzyme that is essential for the survival of all eukaryotic
organisms and plays critical roles in virtually every aspect of DNA metabolism. The enzyme …

Type II topoisomerases regulate DNA topology by making a double-stranded break in one
DNA duplex, transporting another DNA segment through this break and then resealing it …

Type II topoisomerases are essential enzymes that modulate DNA under‐and overwinding,
knotting, and tangling. Beyond their critical physiological functions, these enzymes are the …