The role of lipid components in lipid nanoparticles for vaccines and gene therapy

CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …

Methods of liposomes preparation: formation and control factors of versatile nanocarriers for biomedical and nanomedicine application

D Lombardo, MA Kiselev - Pharmaceutics, 2022 - mdpi.com
Liposomes are nano-sized spherical vesicles composed of an aqueous core surrounded by
one (or more) phospholipid bilayer shells. Owing to their high biocompatibility, chemical …

To PEGylate or not to PEGylate: Immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives

D Shi, D Beasock, A Fessler, J Szebeni… - Advanced drug delivery …, 2022 - Elsevier
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional
formulations utilize PEG as either an active ingredient or an excipient. PEG found its use in …

Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery

L Shi, J Zhang, M Zhao, S Tang, X Cheng, W Zhang… - Nanoscale, 2021 - pubs.rsc.org
The rapid development of drug nanocarriers has benefited from the surface hydrophilic
polymers of particles, which has improved the pharmacokinetics of the drugs. Polyethylene …

Evolution of drug delivery systems: From 1950 to 2020 and beyond

H Park, A Otte, K Park - Journal of Controlled Release, 2022 - Elsevier
Modern drug delivery technology began in 1952 with the advent of the Spansule® sustained-
release capsule technology, which can deliver a drug for 12 h after oral administration …

Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products

M Ibrahim, E Ramadan, NE Elsadek, SE Emam… - Journal of Controlled …, 2022 - Elsevier
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods
and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to …

mRNA vaccines in the COVID-19 pandemic and beyond

MJ Hogan, N Pardi - Annual review of medicine, 2022 - annualreviews.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus
disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around …

Stealth nanoparticles in oncology: Facing the PEG dilemma

S Zalba, TLM Ten Hagen, C Burgui… - Journal of Controlled …, 2022 - Elsevier
Nanoparticles (Nps) have revolutionized the landscape of many treatments, by modifying not
only pharmacokinetic properties of the encapsulated agent, but also providing a significant …

PEGylated lipid nanoparticle formulations: immunological safety and efficiency perspective

R Tenchov, JM Sasso, QA Zhou - Bioconjugate chemistry, 2023 - ACS Publications
Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …

Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization

L van der Koog, TB Gandek… - Advanced healthcare …, 2022 - Wiley Online Library
Over the past decades, lipid‐based nanoparticle drug delivery systems (DDS) have caught
the attention of researchers worldwide, encouraging the field to rapidly develop improved …