Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that has a
notably high incidence in Sardinia. Our study focuses on two HLA class II haplotypes …

BACKGROUND Odorant‐binding proteins (OBPs) in insects are key to detection and
recognition of external chemical signals associated with survival. OBP7 in Spodoptera …

Background The virion infectivity factor (Vif) is an accessory protein, which is essential for
HIV replication in host cells. Vif neutralizes the antiviral host protein APOBEC3 through …

The C-terminal domain of BRCA1 (BRCT) is involved in the DNA repair pathway by
recognizing the pSXXF motif in interacting proteins. It has been reported that short peptides …

Hemagglutinin is the major surface glycoprotein of influenza viruses. It participates in the
initial steps of viral infection through receptor binding and membrane fusion events. The …

Background: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is an enzyme that
isomerizes phosphorylated serine or threonine motifs adjacent to proline residues. Pin1 has …

Flagella of the bacteria Helicobacter pylori and Campylobacter jejuni are important virulence
determinants, whose proper assembly and function are dependent upon glycosylation at …

Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and
differentiation, and is thus pivotal in many cancers. An individual with a high IGF-II level is at …

Since cyanide potentiates the inhibitory activity of several monoamine oxidase (MAO)
inhibitors, a series of carbonitrile-containing aminoheterocycles was examined to explore …

Phosphodiesterase-2 (PDE2) is a key enzyme catalyzing hydrolysis of both cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) that serve as …