Evidence suggests that the perioperative period and the excision of the primary tumour can
promote the development of metastases—the main cause of cancer-related mortality. This …

Objective: To quantify benefit and harm of epidural analgesia, compared with systemic
opioid analgesia, in adults having surgery under general anesthesia. Background: It …

Background Three perioperative factors impair host defence against recurrence during
cancer surgery: the surgical stress response, use of volatile anaesthetic, and opioids for …

Background Guidelines to promote the early recovery of patients undergoing major surgery
recommend a restrictive intravenous-fluid strategy for abdominal surgery. However, the …

Background Surgical resection remains the best option for long-term survival in many solid
tumors. Surgery can, however, lead to tumor cell release into the circulation. Data have …

Surgery is an important treatment modality for the majority of solid organ cancers.
Unfortunately, cancer recurrence following surgery of curative intent is common, and …

Volatile general anesthetics continue to be an important part of clinical anesthesia
worldwide. The impact of volatile anesthetics on the immune system has been investigated …

Background Regional anesthesia and analgesia reduce the stress response to surgery and
decrease the need for volatile anesthesia and opioids, thereby preserving cancer-specific …

Thoracic epidural anaesthesia (TEA) reduces cardiac and splanchnic sympathetic activity
and thereby influences perioperative function of vital organ systems. A recent meta-analysis …

Objective To evaluate 'days at home up to 30 days after surgery'(DAH30) as a patient-
centred outcome measure. Design Prospective cohort study. Data source Using clinical trial …