Prodromal Parkinson disease subtypes—key to understanding heterogeneity
D Berg, P Borghammer, SM Fereshtehnejad… - Nature Reviews …, 2021 - nature.com
In Parkinson disease (PD), pathological processes and neurodegeneration begin long
before the cardinal motor symptoms develop and enable clinical diagnosis. In this prodromal …
before the cardinal motor symptoms develop and enable clinical diagnosis. In this prodromal …
Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches
In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur
in different brain regions. These changes correlate with a range of clinical features, both …
in different brain regions. These changes correlate with a range of clinical features, both …
Non-motor features of Parkinson disease
AHV Schapira, KR Chaudhuri, P Jenner - Nature Reviews …, 2017 - nature.com
Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …
Clinical neurology and epidemiology of the major neurodegenerative diseases
MG Erkkinen, MO Kim… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …
older adults. Most clinicians who care for the elderly are not trained to diagnose these …
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases
are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from …
are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from …
Parkinson's disease dementia: a neural networks perspective
J Gratwicke, M Jahanshahi, T Foltynie - Brain, 2015 - academic.oup.com
In the long-term, with progression of the illness, Parkinson's disease dementia affects up to
90% of patients with Parkinson's disease. With increasing life expectancy in western …
90% of patients with Parkinson's disease. With increasing life expectancy in western …
How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: comparison …
GT Stebbins, CG Goetz, DJ Burn, J Jankovic… - Movement …, 2013 - Wiley Online Library
Background Formulas were developed to define tremor dominant (TD) and postural
instability/gait difficulty (PIGD) phenotypes of Parkinson's Disease (PD) using the Movement …
instability/gait difficulty (PIGD) phenotypes of Parkinson's Disease (PD) using the Movement …
The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort
CH Williams-Gray, SL Mason, JR Evans… - Journal of Neurology …, 2013 - jnnp.bmj.com
Background Prognosis in Parkinson's disease (PD) remains poorly understood due to a lack
of unbiased data on the natural history of treated PD. The CamPaIGN study has been the …
of unbiased data on the natural history of treated PD. The CamPaIGN study has been the …
Parkinson disease subtypes
MA Thenganatt, J Jankovic - JAMA neurology, 2014 - jamanetwork.com
Importance It is increasingly evident that Parkinson disease (PD) is not a single entity but
rather a heterogeneous neurodegenerative disorder. Objective To evaluate available …
rather a heterogeneous neurodegenerative disorder. Objective To evaluate available …
Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease
Cognitive impairment in patients with Parkinson's disease is gaining increased clinical
significance owing to the relative success of therapeutic approaches to the motor symptoms …
significance owing to the relative success of therapeutic approaches to the motor symptoms …