[HTML][HTML] Histidine-based ionizable cationic surfactants: novel biodegradable agents for hydrophilic macromolecular drug delivery
The aim of this study was to design surfactants based on histidine (His) for hydrophobic ion-
pairing and evaluate their safety and efficacy. Lauryl, palmitoyl and oleyl alcohol, as well as …
pairing and evaluate their safety and efficacy. Lauryl, palmitoyl and oleyl alcohol, as well as …
[HTML][HTML] Oral formulations for highly lipophilic drugs: Impact of surface decoration on the efficacy of self-emulsifying drug delivery systems
M Sandmeier, J Hoeng, SS Jensen… - Journal of Colloid and …, 2025 - Elsevier
Aim To evaluate the impact of the surface decoration of cannabidiol (CBD) loaded self-
emulsifying drug delivery systems (SEDDS) on the efficacy of the formulations to cross the …
emulsifying drug delivery systems (SEDDS) on the efficacy of the formulations to cross the …
[HTML][HTML] Interactions of oral permeation enhancers with lipid membranes in simulated intestinal environments
NW Larsen, S Kostrikov, MB Hansen… - International Journal of …, 2024 - Elsevier
The oral bioavailability of therapeutic peptides is generally low. To increase peptide
transport across the gastrointestinal barrier, permeation enhancers are often used. Despite …
transport across the gastrointestinal barrier, permeation enhancers are often used. Despite …
QbD Approach-Based Preparation and Optimization of Hydrophobic Ion-Pairing Complex of Lysozyme with Sodium Dodecyl Sulphate to Enhance Stability in Lipid …
Hydrophobic ion pairing (HIP) complexation was found to be an efficient approach in
modulating the release and enhancing the stability and encapsulation of hydrophilic …
modulating the release and enhancing the stability and encapsulation of hydrophilic …
Re-engineering lysozyme solubility and activity through surfactant complexation
Hydrophobic ion-pairing is an established solubility engineering technique that uses
amphiphilic surfactants to modulate drug lipophilicity and facilitate encapsulation in …
amphiphilic surfactants to modulate drug lipophilicity and facilitate encapsulation in …