Lower respiratory tract infections (LRTIs) are inherited disorders which often causes chronic
respiratory infections for which patients repeatedly receive oral antibiotics, particularly …

Welcome to the 29th edition of Nelson's Pediatric Antimicrobial Therapy, the third edition
written during the COVID-19 pandemic, which continues to significantly affect our lives and …

Antibiotic-resistant bacteria associated with LRTIs are frequently associated with inefficient
treatment outcomes. Antibiotic-resistant Streptococcus pneumoniae, Haemophilus …

Many of the current pandemic threats are caused by viruses that infect the respiratory tract.
Remarkably though, the majority of vaccines and antiviral drugs are administered via …

Multidrug-resistant Gram-negative bacteria present an urgent and formidable threat to the
global public health. Polymyxins have emerged as a last-resort therapy against these …

Abstract Background In the United States (US) and in Europe, cystic fibrosis (CF) qualifies as
a rare disease, thus positioning the field to benefit from regulatory incentives provided by …

Respiratory infection caused by multi-drug resistant (MDR) Pseudomonas aeruginosa is
challenging to treat. In this study, we investigate the optimal dose of anti-pseudomonas …

The major cause of mortality in people with cystic fibrosis (pwCF) is progressive lung
disease characterised by acute and chronic infections, the accumulation of mucus, airway …

Lipopolysaccharide (LPS) is a critical component of the extracellular leaflet within the
bacterial outer membrane, forming an effective physical barrier against environmental …

Pseudomonas aeruginosa (PA), one of the ESKAPE pathogens, is an opportunistic Gram-
negative bacterium responsible for nosocomial infections in humans but also for infections in …