c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth
factor, activates a wide range of different cellular signaling pathways, including those …

Activated pancreatic stellate cells (PSCs) are the main effector cells in the process of
fibrosis, a major pathological feature in pancreatic diseases that including chronic …

The preclinical drug screening of pancreatic cancer treatments suffers from the absence of
appropriate models capable to reproduce in vitro the heterogeneous tumor …

The signaling pathway of the receptor tyrosine kinase MET and its ligand hepatocyte growth
factor (HGF) is important for cell growth, survival, and motility and is functionally linked to the …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

Although hypoxia is a major stress on physiological processes, several human populations
have survived for millennia at high altitudes, suggesting that they have adapted to hypoxic …

Immune checkpoint inhibitor therapy has revolutionized the field of cancer immunotherapy.
Even though it has shown a durable response in some solid tumors, several patients do not …

Intrahepatic cholangiocarcinoma is typically characterized by a dense desmoplastic stroma,
of which cancer-associated myofibroblasts (which express α-smooth muscle actin), are a …

Advanced pancreatic ductal adenocarcinoma (PDAC) and hepatocellular carcinoma (HCC)
are non-curable diseases with a particularly poor prognosis. Over the last decade, research …

Purpose To elucidate how hepatic radiofrequency (RF) ablation affects distant extrahepatic
tumor growth by means of two key molecular pathways. Materials and Methods Rats were …