Longitudinal clinical–pathological studies have increasingly recognized the importance of
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …

As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Importance Midlife vascular risk factors have been associated with late-life dementia.
Whether these risk factors directly contribute to brain amyloid deposition is less well …

Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer
disease; however, their interrelatedness remains poorly understood. The complement …

Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Cerebrovascular disease and vascular risk factors are associated with Alzheimer's disease,
but the evidence for their association with other neurodegenerative disorders is limited …

Evidence suggests exposure to particulate matter with aerodynamic diameter< 2.5 μm (PM2.
5) may increase the risk for Alzheimer's disease and related dementias. Whether PM2. 5 …

Disease-modifying treatments for Alzheimer disease (AD) have focused mainly on reducing
levels of amyloid-β (Aβ) in the brain. Some compounds have achieved this goal, but none …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

Objective The pathologic indices of Alzheimer disease, cerebrovascular disease, and Lewy
body disease accumulate in the brains of older persons with and without dementia, but the …