Background White matter hyperintensities (WMH) are frequently found in Alzheimer's
disease (AD). Commonly considered as a marker of cerebrovascular disease, regional …

Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction and dementia.
Brain imaging may provide important clues about underlying processes. This review focuses …

Arterial stiffness is emerging as an important risk marker for poor brain aging and dementia
through its associations with cerebral small vessel disease, stroke, β-amyloid deposition …

Introduction We examine the role of brain apolipoprotein B (apoB) as a putative marker of
early tau pathology and cognitive decline. Methods Cerebrospinal fluid (CSF) samples from …

We examined the relationships of antemortem vascular risk factors to postmortem
cerebrovascular and Alzheimer's disease (AD) pathologies. Eighty-four AD patients …

Background Cerebral small vessel disease (CSVD) comprises a variety of disorders
affecting small arteries and microvessels of the brain, manifesting as white matter …

Importance Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of
cognitive impairment in the elderly. However, few studies have evaluated the relationship …

Objective Midlife vascular risk factors (MVRFs) are associated with incident dementia, as are
amyloid β (Aβ) deposition and neurodegeneration. Whether vascular and Alzheimer disease …

Human apolipoprotein E (apoE) exists in three isoforms: apoE2, apoE3 and apoE4. APOE
ε4 is a major genetic risk factor for cardiovascular disease (CVD) and Alzheimer's disease …

Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in
subjects with cognitive impairment. However, the relationship between CVD, amyloid …