ATP-binding cassette (ABC) transporters, a large class of transmembrane proteins, are
widely found in organisms and play an important role in the transport of xenobiotics. Insect …

The ATP-binding cassette (ABC) transporters are members of a protein superfamily that are
known to translocate various substrates across membranes, including metabolic products …

The liver is the primary organ for the metabolic degradation of xenobiotics. Transmembrane
transport proteins from the ABC and the SLC families mediate the uptake of endogenous …

The ATP‐binding cassette (ABC) transporters are a superfamily of membrane proteins that
are best known for their ability to transport a wide variety of exogenous and endogenous …

The adenylyl cyclases are variously regulated by G protein subunits, a number of
serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations …

Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …

Reduced glutathione (GSH) is critical for many cellular processes, and both its intracellular
and extracellular concentrations are tightly regulated. Intracellular GSH levels are regulated …

Bile acids (BAs) are important steroidal molecules with a rapidly growing span of
applications across a variety of fields such as supramolecular chemistry, pharmacy, and …

Physiological characteristics of diseases bring about both challenges and opportunities for
targeted drug delivery. Various drug delivery platforms have been devised ranging from …

A key issue in the treatment of many cancers is the development of resistance to
chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them …