Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging
K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
[HTML][HTML] Oxidative stress-based therapeutics in COPD
PJ Barnes - Redox biology, 2020 - Elsevier
Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …
Progress in the mechanism and targeted drug therapy for COPD
C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
Modulating NRF2 in disease: timing is everything
M Dodson, MR de la Vega… - Annual review of …, 2019 - annualreviews.org
The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central
regulator of redox, metabolic, and protein homeostasis that intersects with many other …
regulator of redox, metabolic, and protein homeostasis that intersects with many other …
Broccoli or sulforaphane: is it the source or dose that matters?
There is robust epidemiological evidence for the beneficial effects of broccoli consumption
on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the …
on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the …
Role of Nrf2 and its activators in respiratory diseases
Q Liu, Y Gao, X Ci - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …
Pathological mechanism and targeted drugs of COPD
P Guo, R Li, TH Piao, CL Wang, XL Wu… - International journal of …, 2022 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis, emphysema,
and small airway obstruction. Incompletely reversible airflow limitation, inflammation …
and small airway obstruction. Incompletely reversible airflow limitation, inflammation …