Considering the widespread use of assisted reproductive techniques (ART), DNA
methylation of specific genes involved in spermatogenesis achieves increasingly clinical …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …

Ferroptosis is a type of cell death induced by the iron-dependent accumulation of lipid
hydroperoxides and reactive oxygen species (ROS) in cells. Inhibiting ferroptosis is …

Background Maternal nutrition during pregnancy and infant nutrition in the early postnatal
period (lactation) are critically involved in the development and health of the newborn infant …

Epigenetics refers to the DNA chemistry changes that result in the modification of gene
transcription and translation independently of the underlying DNA coding sequence …

The incidence of neurodevelopmental and neurodegenerative diseases worldwide has
dramatically increased over the last decades. Although the aetiology remains uncertain …

Background Male fertility is progressively declining in many developed countries, but the
relationship between male infertility and environmental factors is still unclear. Objectives To …

Early life adversity (ELA) is associated with a higher risk for diseases in adulthood. Although
the pathophysiological effects of ELA are varied, there may be a unifying role for the immune …

Exposure to any number of stressors during the first 1000 days from conception to age 2
years is important in shaping an individual's life trajectory of health and disease. Despite the …

Despite constant research and public policy efforts, the obesity epidemic continues to be a
major public health threat, and new approaches are urgently needed. It has been shown that …