Hyaluronic acid: A key ingredient in the therapy of inflammation

A Marinho, C Nunes, S Reis - Biomolecules, 2021 - mdpi.com
Hyaluronic acid (HA) is a natural polymer, produced endogenously by the human body,
which has unique physicochemical and biological properties, exhibiting desirable …

Nanomedicine is more than a supporting role in rheumatoid arthritis therapy

Y Han, S Huang - Journal of Controlled Release, 2023 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disorder that affects the joints. Various
medications successfully alleviate the symptoms of RA in clinical. Still, few therapy strategies …

Ferulic acid nanocapsules as a promising treatment modality for colorectal cancer: Preparation and in vitro/in vivo appraisal

RI El-Gogary, M Nasr, LA Rahsed, MA Hamzawy - Life sciences, 2022 - Elsevier
Aims Ferulic acid is a polyphenolic compound with proven anticancer properties, but it
suffers from low solubility and bioavailability. In the current work, polymeric and lipidic …

Skin targeting by chitosan/hyaluronate hybrid nanoparticles for the management of irritant contact dermatitis: In vivo therapeutic efficiency in mouse-ear dermatitis …

KE Abuelella, H Abd-Allah, SM Soliman… - International Journal of …, 2023 - Elsevier
Irritant contact dermatitis (ICD) is an inflammatory skin condition characterized by severe
eczematous lesions. Nanoparticulate drug delivery is the most predominant way to improve …

Polymeric nanoparticles for drug delivery in osteoarthritis

AP Pontes, TJM Welting, J Rip, LB Creemers - Pharmaceutics, 2022 - mdpi.com
Osteoarthritis (OA) is a degenerative musculoskeletal disorder affecting the whole synovial
joint and globally impacts more than one in five individuals aged 40 and over, representing …

Targeted treatment for osteoarthritis: drugs and delivery system

L Mao, W Wu, M Wang, J Guo, H Li, S Zhang, J Xu… - Drug …, 2021 - Taylor & Francis
The management of osteoarthritis (OA) is a clinical challenge due to the particular avascular,
dense, and occluded tissue structure. Despite numerous clinical reports and animal studies …

[HTML][HTML] Micro-and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

Z Nabizadeh, M Nasrollahzadeh… - Beilstein Journal of …, 2022 - beilstein-journals.org
Osteoarthritis, which typically arises from aging, traumatic injury, or obesity, is the most
common form of arthritis, which usually leads to malfunction of the joints and requires …

A review of hyaluronic acid-based therapeutics for the treatment and management of arthritis

P Walvekar, P Lulinski, P Kumar… - International Journal of …, 2024 - Elsevier
Hyaluronic acid (HA), a biodegradable, biocompatible and non-immunogenic therapeutic
polymer is a key component of the cartilage extracellular matrix (ECM) and has been widely …

PEGylated and functionalized polylactide-based nanocapsules: An overview

MA de Oliveira, RS Araújo, VCF Mosqueira - International Journal of …, 2023 - Elsevier
Polymeric nanocapsules (NC) are versatile mixed vesicular nanocarriers, generally
containing a lipid core with a polymeric wall. They have been first developed over four …

Development and evaluation of novel leflunomide SPION bioemulsomes for the intra-articular treatment of arthritis

H Abbas, HA Gad, NS El Sayed, LA Rashed… - Pharmaceutics, 2022 - mdpi.com
Systemic treatments for rheumatoid arthritis are associated with many side effects. This study
aimed to minimize the side effects associated with the systemic administration of leflunomide …