CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

The tissues are the site of many important immunological reactions, yet how the immune
system is controlled at these sites remains opaque. Recent studies have identified Foxp3+ …

CD8 T cells expressing granzyme K are enriched in synovial tissue from patients with
rheumatoid arthritis and in tissues affected by several other autoimmune diseases. The roles …

Resistance to clinical malaria takes years to develop even in hyperendemic regions and
sterilizing immunity has rarely been observed. To evaluate the maturation of the host …

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the CNS
characterized by the production of disease-specific autoantibodies against aquaporin-4 …

Introduction Chronic Pelvic Pain Syndrome or Chronic Prostatitis (CPPS/CP) is the most
prevalent urologic affliction among young adult men. It is a challenging condition to treat …

Human skin has long been known as a protective organ, acting as a mechanical barrier
towards the external environment. More recent is the acquisition that in addition to this …

Gastrointestinal cancers, which include a variety of esophageal and colorectal
malignancies, present a global health challenge and require effective treatment strategies …

Emerging studies have identified the critical roles of tissue-resident memory CD8+ T (T RM)
and B (B RM) cells in the protection against mucosal viral infections, but the underlying …

Background Pancreatic cancer is characterized by metabolic dysregulation and unique
immunological profiles. Nevertheless, the comprehensive understanding of immune and …