Frozen shoulder is a common debilitating disorder characterized by shoulder pain and
progressive loss of shoulder movement. Frozen shoulder is frequently associated with other …

Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …

The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

The extracellular matrix (ECM) is a key determinant of cancer progression and prognosis.
Here we report findings from one of the largest pan-cancer analyses of ECM gene …

In recent years, breakthroughs have been made in tumor immunotherapy. However, tumor
immunotherapy, particularly anti-PD-1/PD-L1 immune checkpoint inhibitors, is effective in …

The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …

Bispecific antibodies (bsAb) that target two independent epitopes or antigens have been
extensively explored in translational and clinical studies since they were first developed in …

Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important
component of the extracellular matrix. This leads to the remodelling of the extracellular …

Transforming growth factor-β (TGF-β) signaling is essential in embryo development and
maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on …