Chronic urticaria (CU) is a mast cell (MC)‐dependent disease with limited therapeutic
options. Current management strategies are directed at inhibiting IgE‐mediated activation of …

Immunoglobulin (Ig) superfamily proteins play diverse roles in vertebrates, including
regulation of cellular responses by sensing endogenous or exogenous ligands. Siglecs are …

Siglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-
binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged …

Mast cells have existed for millions of years in species that never suffer from allergic
reactions. Hence, in addition to allergies, mast cells can play a critical role in homeostasis …

Microglia are resident myeloid cells in the central nervous system (CNS) with a unique
developmental origin, playing essential roles in developing and maintaining the CNS …

Background Indolent systemic mastocytosis (ISM) is characterized by excessive mast cell
(MC) accumulation and MC-driven signs and symptoms. Currently used therapies are not …

Background Sialic acid‐binding immunoglobulin‐like lectin (Siglec)‐6 and Siglec‐8 are
closely related mast cell (MC) receptors with broad inhibitory activity, but whose functional …

Background Mast cell activation is critical for the development of allergic diseases. Ligation
of sialic acid–binding immunoglobin-like lectins (Siglecs), such as Siglec-6,-7, and-8 as well …

Glycan-binding receptors known as lectins represent a class of potential therapeutic targets.
Yet, the therapeutic potential of targeting lectins remains largely untapped due in part to …

Estrogen and related receptors have been shown to have a significant impact on human
development, reproduction, metabolism and immune regulation and to play a critical role in …