Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical,
thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of …

Acidosis is a noxious condition associated with inflammation, ischaemia or defective acid
containment. As a consequence, acid sensing has evolved as an important property of …

Venomous animals from distinct phyla such as spiders, scorpions, snakes, cone snails, or
sea anemones produce small toxic proteins interacting with a variety of cell targets. Their …

Study design: This is a narrative review of the literature. Objectives: This review aims to be
useful in identifying therapeutic targets. It focuses on the molecular and biochemical …

Overexpression of the cation-permeable channel TRPM8 in prostate cancers might
represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of …

Transient receptor potential vanilloid receptor subtype 1 (TRPV1) is an ionotropic receptor
activated by temperature and chemical stimuli. The C-terminal region that is adjacent to the …

Given that the pharmacological or genetic inactivation of fatty acid amide hydrolase (FAAH)
counteracts pain and inflammation, and on the basis of the established involvement of …

Prostate cancer (PC) is a major health problem in adult males. TRPM8, a cationic TRP
channel activated by cooling and menthol is upregulated in PC. However, the precise role of …

Pain originating in inflammation is the most common pathologic pain condition encountered
by the anesthesiologist whether in the context of surgery, its aftermath, or in the practice of …

The transient receptor potential vanilloid 1 (TRPV1) channel is a thermosensory receptor
implicated in diverse physiological and pathological processes. The TRP domain, a highly …