Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …

Microglial activation during neuroinflammation is crucial for coordinating the immune
response against neuronal tissue, and the initial response of microglia determines the …

Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination of the
central nervous system (CNS). Autologous hematopoietic cell transplantation (HCT) shows …

The T cell repertoire of healthy mice and humans harbors self-reactive CD4+ conventional T
(Tconv) cells capable of inducing autoimmunity. Using T cell receptor profiling paired with in …

A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain | Science
Translational Medicine news careers commentary Journals Science Science brought to you …

Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring
viral encephalitis as a global research priority. Upon entry of the virus into the CNS, severe …

Compelling evidence has shown that interferon (IFN)-γ has dual effects in multiple sclerosis
and in its animal model of experimental autoimmune encephalomyelitis (EAE), with results …

Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative
disorder characterized by the loss of upper and lower motor neurons in the brain and spinal …

Amyotrophic lateral sclerosis (ALS) is characterized by selective and progressive
neurodegenerative changes in motor neural networks. Given the system complexity …