Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's
declining function and the development of pain, it may affect one's physical health, mental …

The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the
spine. With little inherent regenerative capacity, degeneration of the intervertebral disc …

In this study, we used single-cell transcriptomic analysis to identify new specific biomarkers
for nucleus pulposus (NP) and inner annulus fibrosis (iAF) cells, and to define cell …

The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae.
Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs …

Although previous RNA sequencing methods have been widely used in orthopedic research
and have provided ideas for therapeutic strategies, the specific mechanisms of some …

As a global public health problem, low back pain (LBP) caused by intervertebral disc
degeneration (IDD) seriously affects patients' quality of life. In addition, the prevalence of …

The complexity of the human intervertebral disc (IVD) has hindered the elucidation of the
microenvironment and mechanisms underlying IVD degeneration (IVDD). Here we …

Background: Intervertebral disc degeneration (IDD), characterized by diverse pathological
changes, causes low back pain (LBP). However, prophylactic and delaying treatments for …

Over the past decade, single-cell RNA sequencing (scRNA-seq) has revolutionized
research on biological mechanisms of diseases. Moreover, this technique has been utilized …

Intervertebral disc (IVD) degeneration is characterized by a loss of cellularity, and changes
in cell-mediated activity that drives anatomic changes to IVD structure. In this study, we used …