The field of cell-based screening is expanding rapidly as innovations in target selection and
instrumentation increase the number of targets that can be efficiently screened in cellular …

Scintillation proximity assays (SPAs) have become a powerful tool for high-throughput
screening (HTS) because they can measure the activity and binding of very diverse classes …

Several observations indicate that late-G1/S-phase-specific cellular functions may be
required for herpes simplex virus (HSV) replication:(i) certain mutant HSV strains are …

Increased expression or activity of c-Src tyrosine kinase has been associated with the
transformed phenotype in tumor cells and with progression of neoplastic disease. A number …

We have expressed the human excitatory amino acid transporters EAAT1, EAAT2 and
EAAT3 stably in HEK293 cells and characterized the transporters pharmacologically in a …

Background Despite years of interest in the anti-cancerous effects of cardiac glycosides
(CGs), and numerous studies in vitro and in animals, it has not yet been possible to utilize …

CHS 828, a novel pyridyl cyanoguanidine, has shown potent antitumour activity both in vitro
and in vivo and is currently undergoing phase I evaluation in humans in collaboration with …

Peptichemio, a mixture of six short oligopeptides all comprising the alkylating amino acid mL-
sarcolysin, has shown clinical activity in several malignancies. Previous studies have …

Background There are controversial results on the efficacy of the abandoned, intrathecal
predominant methylprednisolone application in multiple sclerosis (MS) in contrast to the …

CHS 828, a newly recognized pyridyl cyanoguanidine, has shown promising antitumor
activity both in vitro and in vivo and is presently in early phase I clinical trial in collaboration …