The deposition of highly phosphorylated and aggregated tau is a characteristic of
tauopathies, including Alzheimer's disease. It has long been known that different isoforms of …

Background Biomarker changes that occur in the period between normal cognition and the
diagnosis of sporadic Alzheimer's disease have not been extensively investigated in …

Alzheimer's disease (AD) is prevalent around the world, yet our understanding of the
disease is still very limited. Recent work suggests that the cornerstone of AD may include the …

Abstract Growth-associated protein 43 (GAP-43) is known as a neuronal plasticity protein
because it is widely expressed at high levels in neuronal growth cones during axonal …

Electrochemical surface-enhanced Raman spectroscopy (E-SERS) is a powerful technique
for the detection of trace levels of analytes in solution. It has wide ranging applications with a …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease, with a complex
pathogenesis and an irreversible course. Therefore, the early diagnosis of AD is particularly …

Correlative light-electron microscopy (CLEM) has evolved in the last decades, especially
after significant developments in sample preparation, imaging acquisition, software, spatial …

Aging is a natural and inevitable process in all living organisms, characterized by the
decline of physiological functions and increased susceptibility to age-related diseases (de …

Alzheimer's disease (AD) and dementia constitute significant challenges to global
healthcare systems, as a result of increasing life expectancy that leads to a larger population …

Latent HIV-1 reservoirs are a major obstacle to the eradication of HIV-1. Several cure
strategies have been proposed to eliminate latent reservoirs. One of the key strategies …