Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several
complementary effects on cellular function that are favourable to healthspan; it is often …

The sirtuin 1 (SIRT1) activator resveratrol has emerged as a promising candidate for the
prevention of vascular oxidative stress, which is a trigger for endothelial dysfunction …

The improvements in healthcare services and quality of life result in a longer life expectancy
and a higher number of aged individuals, who are inevitably affected by age-associated …

Disorders of metabolism affect multiple systems throughout the body, but may have the
greatest impact on both central and peripheral nervous systems. Current available …

The cellular mechanisms and signaling network that guide the cardiac disease
pathophysiology are inextricably intertwined, which explains the current scarcity of effective …

Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …

Background: Selenium and coenzyme Q10 (SeQ10) possess antioxidant and anti-
inflammatory properties, potentially mediated via Sirtuin1 (SIRT1). We aimed to investigate …

Vascular endothelial dysfunction (VED) is linked with the pathogenesis of obstructive sleep
apnea (OSA) comorbidities, such as cardiovascular disease. Astragaloside IV (As-IV) has …