Smoking is a well-known risk factor for cardiovascular diseases. However, the mechanisms
behind how smoking leads to vasospasm are not fully elucidated. Endothelin receptors are …

Ursolic acid (UA) mediates the vasorelaxant activity via nitric oxide (NO) release, and
upregulation of endothelial nitric oxide synthase (eNOS) in endothelial cells (ECs) in …

Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and
multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin …

The hallmark of the coronavirus disease 2019 (COVID‐19) pathophysiology was reported to
be an inappropriate and uncontrolled immune response, evidenced by activated …

Pathological myocardial remodeling was still one of the leading causes of death worldwide
with an unmet therapeutic need. A growing number of researchers have addressed the role …

Aging is characterized by a progressive loss of cellular functions that increase the risk of
developing chronic diseases, vascular dysfunction, and neurodegenerative conditions. The …

In a murine model of acute ischemic stroke, SIRT6 knockdown resulted in larger cerebral
infarct size, worse neurological outcome, and higher mortality, indicating a possible neuro …

In endothelial cells, miR-148a-3p is involved in several pathological pathways, including
chronic inflammatory conditions. However, the molecular mechanism of miR-148a-3p in …

Sirtuins (SIRTs) belong to the family of nicotine adenine dinucleotide (NAD+)-dependent
class III histone deacetylases, which come into play in the regulation of epigenetic …

Germline mutations in Breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2)
cause breast, ovarian, and other cancers, and the chemotherapeutic drug doxorubicin (Dox) …