Plasma Exosomal miR-199a-5p Derived from Preeclampsia with Severe Features Impairs Endothelial Cell Function via Targeting SIRT1

Z Chen, M Wu, H Huang, H Tao, L Zou, Q Luo - Reproductive Sciences, 2022 - Springer
Preeclampsia (PE) is a pregnancy complication with high maternal and fetal morbidity and
mortality rates. During pregnancy, the concentration of exosomes in the maternal blood …

Sirtuin 2 in vascular ageing: the forsaken child?

YM Puspitasari - European Heart Journal, 2023 - academic.oup.com
Arterial stiffness holds clinical significance as an independent predictor for CV events and
stroke. 12, 13 One well-known component contributing to the development of age-related …

Serum proteomic biomarker investigation of vascular depression using data-independent acquisition: a pilot study

L Lan, S Peng, R Zhang, H He, Y Yang, B Xi… - Frontiers in Aging …, 2024 - frontiersin.org
Background Vascular depression (VaD) is a depressive disorder closely associated with
cerebrovascular disease and vascular risk factors. It remains underestimated owing to …

[HTML][HTML] Dental pulp stem cells ameliorate D-galactose-induced cardiac ageing in rats

G El-Akabawy, SOF El-Kersh, AOFO El-Kersh, SN Amin… - PeerJ, 2024 - peerj.com
Background Ageing is a key risk factor for cardiovascular disease and is linked to several
alterations in cardiac structure and function, including left ventricular hypertrophy and …

[HTML][HTML] Ginsenoside Rb1 prevents age-related endothelial senescence by modulating SIRT1/caveolin-1/enos signaling pathway

B Zhou, G Shi, D Xie, X Zhao, B Hao, D Liu, M Wang… - Heliyon, 2024 - cell.com
Background Advancing age is one of the independent risk factors for cardiovascular
disorders. The Compendium of Materia Medica, a classic book on traditional Chinese …

Association of SIRT1 with metabolic parameters and aging rate

O Kolesnikova, O Zaprovalna… - Biomedical …, 2023 - bmrat.biomedpress.org
Introduction: SIRT1 has attracted great interest due to its role as a regulator of longevity, and
its therapeutic potential for the prevention and treatment of aging and age-related …

Cellular and molecular determinants of arterial aging

P Lacolley, P Challande, V Regnault, EG Lakatta… - Early Vascular Aging …, 2024 - Elsevier
A number of key signaling pathways are highly relevant to early vascular aging. These are
overviewed here to provide a context for understanding the initiation and progression of …

[HTML][HTML] The role of nitric oxide on the antiarrhythmic effects of ketamine/xylazine in a rat model of acute cardiac ischemia-reperfusion

A Imani, SF Rajani, K Rakhshan, M Faghihi… - Current Research in …, 2022 - Elsevier
The prevalence of ventricular arrhythmias during general anesthesia is about 70%. In
experimental studies on the antiarrhythmic effects of different agents, using anesthetic drugs …

[HTML][HTML] Waterpipe Smoke Inhalation Induces Lung Injury and Aortic Endothelial Dysfunction in Mice

A Nemmar, S Beegam, NE Zaaba, O Elzaki… - Physiological …, 2023 - ncbi.nlm.nih.gov
Waterpipe tobacco smoking (WPS) inhalation has been shown to trigger endothelial
dysfunction and atherosclerosis. However, the mechanisms underlying these effects are still …

Recent insights concerning autophagy and endothelial cell nitric oxide generation

SK Park, JM Cho, S Mookherjee, PW Pires… - Current Opinion in …, 2022 - Elsevier
Although endothelial cell (EC) dysfunction contributes to the etiology of more diseases than
any other tissue in the body, EC metabolism is an understudied therapeutic target. Evidence …