Anticoagulants are used to prevent clot formation both in vitro and in vivo. In the specific field
of in vitro diagnostics, anticoagulants are commonly added to collection tubes either to …

(1) Baroreceptor function: In lowoutput HF models, there is attenuation of carotid sinus
baroreceptor discharge sensitivity. Administration of digoxin produces improvement in …

For many drugs, finding the balance between efficacy and toxicity requires monitoring their
concentrations in the patient's blood. Quantifying drug levels at the bedside or at home …

After 200 years of use, digitalis still appears to have a place in our armamentarium for heart
failure and atrial fibrillation despite the proven survival benefits with ACE inhibitors and β …

A biosensor is a sensor that uses biological selectivity to limit its perception to particular key
molecules and can be defined as an analytical device possessing a biological or …

The term “immunoassay” refers to a diverse group of analytical techniques which are found
throughout clinical laboratories. In this article, an immunoassay is defined as an analytical …

É importante salientar, entretanto, que a parcela de estudos em IC aguda só passou a ser
expressiva na última década, em que foram publicados grandes registros e também os …

Therapeutic drug monitoring is a common practice in clinical studies. It requires the
quantification of drugs in biological fluids. Micellar liquid chromatography (MLC), a well …

Flecainide, a cardiac class 1C blocker of the surface membrane sodium channel (NaV1. 5),
has also been reported to reduce cardiac ryanodine receptor (RyR2)-mediated …

A simple, accurate and selective LC–MS/MS method was developed and validated for
simultaneous quantification of ten antiarrhythic drugs (diltiazem, amiodarone, mexiletine …