Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

A Grifoni, T Alonzi, G Alter, DMC Noonan… - Frontiers in …, 2023 - frontiersin.org
Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …

One population, multiple lifestyles: commensalism and pathogenesis in the human mycobiome

DM Proctor, RA Drummond, MS Lionakis, JA Segre - Cell host & microbe, 2023 - cell.com
Candida auris and Candida albicans can result in invasive fungal diseases. And yet, these
species can stably and asymptomatically colonize human skin and gastrointestinal tracts. To …

[HTML][HTML] Multi-'omics of gut microbiome-host interactions in short-and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients

R Xiong, C Gunter, E Fleming, SD Vernon, L Bateman… - Cell host & …, 2023 - cell.com
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, debilitating
disorder manifesting as severe fatigue and post-exertional malaise. The etiology of ME/CFS …

Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures

S Pang, X Chen, Z Lu, L Meng, Y Huang, X Yu… - Nature Aging, 2023 - nature.com
Centenarians are an excellent model to study the relationship between the gut microbiome
and longevity. To characterize the gut microbiome signatures of aging, we conducted a …

Contribution of the patient microbiome to surgical site infection and antibiotic prophylaxis failure in spine surgery

DR Long, C Bryson-Cahn, A Waalkes… - Science Translational …, 2024 - science.org
Despite modern antiseptic techniques, surgical site infection (SSI) remains a leading
complication of surgery. However, the origins of SSI and the high rates of antimicrobial …

Ancient dental calculus reveals oral microbiome shifts associated with lifestyle and disease in Great Britain

AS Gancz, AG Farrer, MP Nixon, S Wright… - Nature …, 2023 - nature.com
The prevalence of chronic, non-communicable diseases has risen sharply in recent
decades, especially in industrialized countries. While several studies implicate the …

Baseline gut microbiome signatures correlate with immunogenicity of SARS-CoV-2 mRNA vaccines

L Daddi, Y Dorsett, T Geng, S Bokoliya, H Yuan… - International Journal of …, 2023 - mdpi.com
The powerful immune responses elicited by the mRNA vaccines targeting the SARS-CoV-2
Spike protein contribute to their high efficacy. Yet, their efficacy can vary greatly between …

Gut microbiome in healthy aging versus those associated with frailty

MY Lim, YD Nam - Gut Microbes, 2023 - Taylor & Francis
As the proportion of older people in the world's population steadily increases, there is an
urgent need to identify ways to support healthy aging. The gut microbiome has been …

Harnessing human microbiomes for disease prediction

Y Liu, M Fachrul, M Inouye, G Méric - Trends in microbiology, 2024 - cell.com
The human microbiome has been increasingly recognized as having potential use for
disease prediction. Predicting the risk, progression, and severity of diseases holds promise …

Skin microbiome attributes associate with biophysical skin ageing

W Zhou, E Fleming, G Legendre, L Roux… - Experimental …, 2023 - Wiley Online Library
Two major arms of skin ageing are changes in the skin's biophysical conditions and
alterations in the skin microbiome. This work partitioned both arms to study their interaction …