Chronic pain affects the life quality of the suffering patients and posts heavy problems to the
health care system. Conventional medications are usually insufficient for chronic pain …

Inflammation plays a significant role in the occurrence and development of multiple
diseases. This study comprehensively reviews and presents literature from the last five …

Background Complex regional pain syndrome type-I (CRPS-I) causes excruciating pain that
affect patients' life quality. However, the mechanisms underlying CRPS-I are incompletely …

Background Paclitaxel is a widely prescribed chemotherapy drug for treating solid tumors.
However, paclitaxel-induced peripheral neuropathy (PIPN) is a common adverse effect …

Background Gout results from disturbed uric acid metabolism, which causes urate crystal
deposition in joints and surrounding tissues. Gout pain management is largely limited to …

Excessive deposition of monosodium urate (MSU) crystal in the joint results in gout arthritis,
which triggers severe pain and affects life quality. Oxidative stress is a pivotal mechanism …

Although pain is regarded as a global public health priority, analgesic therapy remains a
significant challenge. Pain is a hypersensitivity state caused by peripheral and central …

Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and
inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 …

Abstract Background Complex Regional Pain Syndrome (CRPS) leads to a debilitating
chronic pain condition. The lack of cause, etiology, and treatment for CRPS has been widely …

Electroacupuncture (EA) is effective in various chronic pains. NF-κB and CXCL12 modulate
the formation of chronic pain. Herein, we hypothesized that EA alleviates cancer-induced …