Genetics and epigenetics in obesity
K Rohde, M Keller, L la Cour Poulsen, M Blüher… - Metabolism, 2019 - Elsevier
Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …
markedly increased over the last decades. Obesity maybe considered a heritable trait …
Epigenetics of type 2 diabetes mellitus and weight change—a tool for precision medicine?
Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations
A Qasim, M Turcotte, RJ de Souza… - Obesity …, 2018 - Wiley Online Library
Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …
detrimental impact on human health persist through evolutionary time? Numerous …
[HTML][HTML] Recent progress in epigenetics of obesity
FY Wu, RX Yin - Diabetology & Metabolic Syndrome, 2022 - Springer
Nowadays, obesity is one of the largest public health problems worldwide. In the last few
decades, there has been a marked increase in the obesity epidemic and its related …
decades, there has been a marked increase in the obesity epidemic and its related …
[HTML][HTML] Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers
The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …
CD36 in atherosclerosis: pathophysiological mechanisms and therapeutic implications
K Tian, Y Xu, A Sahebkar, S Xu - Current atherosclerosis reports, 2020 - Springer
Abstract Purpose of Review Atherosclerosis is a chronic disease characterized by lipid
retention and inflammation in the artery wall. The retention and oxidation of low-density …
retention and inflammation in the artery wall. The retention and oxidation of low-density …
[HTML][HTML] FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis
Abstract Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown
adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we …
adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we …
Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond
Z Cheng, L Zheng, FA Almeida - The Journal of nutritional biochemistry, 2018 - Elsevier
Environmental factors (eg, malnutrition and physical inactivity) contribute largely to
metabolic disorders including obesity, type 2 diabetes, cardiometabolic disease and …
metabolic disorders including obesity, type 2 diabetes, cardiometabolic disease and …
[HTML][HTML] Molecular basis of ageing in chronic metabolic diseases
Aim Over the last decades, the shift in age distribution towards older ages and the
progressive ageing which has occurred in most populations have been paralleled by a …
progressive ageing which has occurred in most populations have been paralleled by a …
Epigenetic regulation of insulin action and secretion–role in the pathogenesis of type 2 diabetes
C Ling - Journal of internal medicine, 2020 - Wiley Online Library
The prevalence of type 2 diabetes (T2D) is rapidly increasing worldwide. Obesity, physical
inactivity and ageing increase the risk of T2D. Epigenetic modifications can change due to …
inactivity and ageing increase the risk of T2D. Epigenetic modifications can change due to …