The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark
pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary …

Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes
throughout life, but the functions of OPCs are not limited to oligodendrogenesis. Here we …

Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative
diseases, so understanding oligodendrocyte activation states would shed light on disease …

The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …

Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …

The synapse is the focus of experimental research and theory on the cellular mechanisms of
nervous system plasticity and learning, but recent research is expanding the consideration …

Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small
arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological …

Oligodendrocytes myelinate axons in the central nervous system and develop from
oligodendrocyte precursor cells (OPCs) that must first migrate extensively during brain and …

The number of patients surviving with congenital heart disease (CHD) has soared over the
last 3 decades. Adults constitute the fastest-growing segment of the CHD population, now …