Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

M Ashrafizadeh, K Hushmandi… - Bioengineering & …, 2023 - Wiley Online Library
Green chemistry has been a growing multidisciplinary field in recent years showing great
promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an …

Chitosan-based nanoparticles for nucleic acid delivery: technological aspects, applications, and future perspectives

M Karayianni, T Sentoukas, A Skandalis, N Pippa… - Pharmaceutics, 2023 - mdpi.com
Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which is
an abundant carbohydrate found mainly in the shells of various marine and terrestrial …

Engineered extracellular vesicles derived from dermal fibroblasts attenuate inflammation in a murine model of acute lung injury

AI Salazar‐Puerta, MA Rincon‐Benavides… - Advanced …, 2023 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) represents a significant burden to the
healthcare system, with≈ 200 000 cases diagnosed annually in the USA. ARDS patients …

Chitosan/silk fibroin composite bilayer PCL nanofibrous mats for bone regeneration with enhanced antibacterial properties and improved osteogenic potential

X Wang, Y Peng, Y Wu, S Cao, H Deng… - International Journal of …, 2023 - Elsevier
In regenerative medicine and bone tissue engineering, various composite materials are
enormously popular, but the final tissue restoration outcome is not always satisfactory. In this …

Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications

J Yang, KM Luly, JJ Green - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …

[HTML][HTML] Interleukins, growth factors, and transcription factors are key targets for gene therapy in osteoarthritis: a scoping review

M Uebelhoer, C Lambert, J Grisart, K Guse… - Frontiers in …, 2023 - frontiersin.org
Objective: Osteoarthritis (OA) is the most common degenerative joint disease, characterized
by a progressive loss of cartilage associated with synovitis and subchondral bone …

[HTML][HTML] Natural products can modulate inflammation in intervertebral disc degeneration

Z Liu, J Zhu, H Liu, C Fu - Frontiers in Pharmacology, 2023 - frontiersin.org
Intervertebral discs (IVDs) play a crucial role in maintaining normal vertebral anatomy as
well as mobile function. Intervertebral disc degeneration (IDD) is a common clinical symptom …

[HTML][HTML] Non-viral reprogramming of human nucleus pulposus cells with FOXF1 via extracellular vesicle delivery: an in vitro and in vivo study

S Tang, A Salazar-Puerta, J Richards… - European cells & …, 2021 - ncbi.nlm.nih.gov
Intervertebral disc (IVD) degeneration is characterized by decreased cellularity and
proteoglycan synthesis and increased inflammation, catabolism, and neural/vascular …

Biomembrane-wrapped gene delivery nanoparticles for cancer therapy

J Li, H Zeng, L Li, M Song, M Dong - Frontiers in Bioengineering and …, 2023 - frontiersin.org
As a promising strategy, gene delivery for cancer treatment accepts encouraging progress
due to the high efficacy, low toxicity and exclusive selectivity. However, the delivery …

ICAM-1-decorated extracellular vesicles loaded with miR-146a and Glut1 drive immunomodulation and hinder tumor progression in a murine model of breast cancer

S Duarte-Sanmiguel, AI Salazar-Puerta, A Panic… - Biomaterials …, 2023 - pubs.rsc.org
Tumor-associated immune cells play a crucial role in cancer progression. Myeloid-derived
suppressor cells (MDSCs), for example, are immature innate immune cells that infiltrate the …