Dendritic cells (DCs), the most efficient antigen-presenting cells, are necessary for the
effective activation of naïve T cells. DCs can also acquire tolerogenic functions in vivo and in …

Simple Summary Epigenetic mechanisms including methylation play an essential role in
regulating gene expression not only in cancer cells but also in immune cells. Although role …

Bacterial extracellular vesicles (BEVs) produced by gut commensal bacteria have been
proposed to play an important role in maintaining host homeostasis via interactions with the …

Plant growth often encounters diverse abiotic stresses. As a global resource-based
ecological problem, salinity is widely distributed and one of the major abiotic stresses …

Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …

Interpreting the function and metabolism of enzymatic DNA modifications requires both
position-specific and global quantities. Sequencing-based techniques that deliver the former …

Background Prenatal exposure to phthalates has been associated with adverse health and
neurodevelopmental outcomes. DNA methylation (DNAm) alterations may be a mechanism …

Rare diseases (RDs), more than 80% of which have a genetic origin, collectively affect
approximately 350 million people worldwide. Progress in next-generation sequencing …

Microglia are myeloid-derived cells recognized as brain-resident macrophages. They act as
the first and main line of immune defense in the central nervous system (CNS). Microglia …

Systemic lupus erythematosus (SLE) is a typical systemic autoimmune disease that
manifests as skin rash, arthritis, lymphadenopathy, and multiple organ lesions. Epigenetics …